Introduction
3-Bromophenol is an essential organic compound used widely in chemical synthesis and industrial applications. This blog post will comprehensively overview 3-Bromo phenol, including its chemical properties, synthesis methods, applications, and safety considerations.
Chemical Properties
Chemical Name: 3-Bromophenol
<strong>CAS Number: 591-20-8
Kemystery ID: C2168B410
Molecular Formula: C6H5BrO
Molecular Weight: 173.01 g/mol
Appearance: Off-white to light brown crystalline solid
Melting Point: 34-36°C
Boiling Point: 235-237°C
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
The structure of 3-Bromophenol consists of a benzene ring substituted with a bromine atom at the meta position and a hydroxyl group at the para position. This arrangement gives 3-Bromophenol its unique chemical reactivity, making it valuable in various chemical transformations.
Synthesis
The synthesis of 3-Bromophenol typically involves the bromination of phenol. Here is a standard synthetic route:
- Direct Bromination: Phenol is treated with bromine in the presence of a suitable catalyst, such as ferric bromide (FeBr3) or aluminum bromide (AlBr3). The reaction is carefully controlled to obtain 3-Bromophenol as the primary product.
Applications
It is a versatile compound with numerous organic synthesis, pharmaceuticals, and materials science applications. Some of its primary uses include:
Intermediate in Organic Synthesis:
It is a key synthesizing synthesis of various organic compounds, including dyes, pigments, and agrochemicals. Its bromine and hydroxyl functional groups allow for further chemical modifications.
Pharmaceuticals:
It is used in the pharmaceutical industry as a building block for synthesizing active pharmaceutical ingredients (APIs). Several drugs, including antiseptics and antifungal agents, are synthesized using 3-bromophenol as a precursor.
Material Science:
It is employed in the preparation of specialty polymers and materials. Its reactivity enables the introduction of functional groups necessary for desired material properties.
Research Reagent:
In academic and industrial research, Is is a reagent for studying reaction mechanisms, developing new synthetic methodologies, and exploring chemical reactivity.
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Safety and Handling
While It is a valuable chemical, it is essential to handle it with care due to its potential hazards:
- Toxicity:</substantial> 3-Bromophenol is harmful if ingested, inhaled, or absorbed through the skin. It can irritate the eyes, skin, and respiratory system.
- Carcinogenicity: Prolonged exposure may have carcinogenic effects. It is advisable to handle this compound with appropriate precautions.
- Protective Measures: When working with 3-bromophenol, wear personal protective equipment (PPE) such as gloves, goggles, and lab coats. Conduct experiments in a well-ventilated area or under a fume hood to minimize exposure to vapors and dust.
- Storage: Store It in a cool, dry place away from light and moisture.
Conclusion
It is an essential compound in organic chemistry, offering versatility and reactivity that make it a staple in many laboratories and industries. Despite its numerous applications, it is crucial to adhere to stringent safety protocols to mitigate its hazardous effects. Whether used in pharmaceutical synthesis, material science or as a research reagent, it continues to be a compound of significant interest and utility.
References
For further reading and detailed studies on 3-Bromophenol, consult the following resources:
- “Advanced Organic Chemistry” by Jerry March – A comprehensive guide to organic synthesis and reaction mechanisms.
- “Organic Synthesis” by Michael B. Smith and Jerry March – Detailed methodologies and protocols for organic synthesis.
- PubChem Database – A reliable source for chemical information and properties.
- Chemical Safety Data Sheets (SDS) – Manufacturer-provided safety information for handling and storage of 3-Bromophenol.</li></li>
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