3-Hydroxy Piperidine

Chemical Identity

• IUPAC Name: 3-Hydroxypiperidine
• Molecular Formula: C5H11NO
• Molecular Weight: 101.15 g/mol
• CAS Number: 6859-99-0

Structure and Properties

3-Hydroxy Piperidine is an organic compound belonging to the class of piperidines, which are six-membered heterocyclic compounds containing one nitrogen atom. In 3-Hydroxy Piperidine, a hydroxyl group (-OH) is attached to the third carbon atom in the piperidine ring. The presence of this hydroxyl group significantly influences its chemical reactivity and solubility.

• Physical State: It typically appears as a colorless to pale yellow liquid or crystalline solid.
• Solubility: Soluble in water, ethanol, and various organic solvents, enhancing its versatility in chemical reactions.

Synthesis

3-Hydroxy Piperidine can be synthesized through multiple chemical pathways. Two common methods include:

1. Reduction of 3-Piperidone: This method involves reducing 3-piperidone using suitable reducing agents such as sodium borohydride (NaBH4) or catalytic hydrogenation.
2. Hydrolysis of Precursors: Hydrolysis of appropriate precursors, such as 3-hydroxy-N-protected piperidines, followed by deprotection to yield the free 3-Hydroxy Piperidine.

Applications

3-Hydroxy Piperidine is a valuable intermediate and building block in various chemical and industrial applications:

1. Pharmaceuticals:
   • It serves as an intermediate in the synthesis of numerous pharmacologically active compounds, particularly in the development of drugs targeting neurological disorders and certain types of cancers.
   • Used in the design and synthesis of receptor agonists and antagonists.
2. Agrochemicals:
   • Employed in the synthesis of pesticides, herbicides, and fungicides, contributing to the development of efficient and effective agricultural chemicals.
3. Organic Synthesis:
   • Acts as a reagent and intermediate in the preparation of more complex organic molecules, including fine chemicals and specialty chemicals.
   • Utilized in the synthesis of heterocyclic compounds, which are crucial in medicinal chemistry and material science.

Safety and Handling

As with many chemical substances, proper safety measures must be taken when handling 3-Hydroxy Piperidine:

• Personal Protective Equipment (PPE): Use appropriate PPE, including gloves, goggles, and lab coats, to prevent direct contact with the substance.
• Storage: Store in a cool, dry place away from incompatible materials such as strong oxidizing agents.
• First Aid Measures: In case of contact, follow standard first aid measures. For skin contact, wash thoroughly with soap and water. In case of eye contact, rinse immediately with plenty of water and seek medical attention.

Consult the Material Safety Data Sheet (MSDS) for detailed information on safety protocols and potential hazards.