Overview
4-Bromo phenol is an aromatic organic compound used extensively in chemical syntheses and various industrial applications. Known for its bromine-substituted phenol structure, this compound serves as a valuable intermediate in the production of pharmaceuticals, agrochemicals, and fine chemicals. This post provides a detailed overview of 4-bromophenol, including its chemical properties, applications, and safety measures.
Description
4-Bromo phenol is a white to off-white crystalline solid with a characteristic phenolic odor. It features a bromine atom substituted at the para position of the phenol ring, making it highly reactive and useful in various organic synthesis reactions.
Product Information
- IUPAC Name: 4-Bromo phenol
- Common Name: p-Bromophenol
- CAS Number: 106-41-2
- Molecular Formula: C₆H₅BrO
- Molecular Weight: 173.01 g/mol
- Chemical Structure:
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Applications
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Organic Synthesis
- 4-Bromophenol is widely used as an intermediate in organic synthesis. It is involved in the preparation of various brominated compounds, which are important in the development of pharmaceuticals and fine chemicals.
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Pharmaceuticals
- This compound serves as a building block in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
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Agrochemicals
- Used in the synthesis of agrochemicals, including insecticides, herbicides, and fungicides, contributing to improved agricultural productivity.
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Dyes and Pigments
- Employed in the production of dyes and pigments, providing color and stability to various products.
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Chemical Research
- Utilized in academic and industrial research for studying reaction mechanisms, developing new synthetic methodologies, and producing novel brominated compounds.
Physicochemical Information
- Molecular Formula: C₆H₅BrO
- Molecular Weight: 173.01 g/mol
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Safety Information According to GHS
- Hazard Statements:
- H315: Causes skin irritation
- H319: Causes serious eye irritation
- H335: May cause respiratory irritation
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Precautionary Statements:
- P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
- P280: Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352: IF ON SKIN: Wash with plenty of soap and water.
- P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
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Safety Information
- Hazards: 4-Bromophenol can cause irritation to the skin, eyes, and respiratory system. Handle with care to avoid exposure.
- Protective Measures: Use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. Work with 4-bromophenol should be conducted in a well-ventilated area, preferably in a fume hood.
- Storage: Store in tightly sealed containers, away from light, heat, and incompatible substances.
Storage and Shipping Information
- Storage Conditions: Store in a cool, dry place in tightly sealed containers. Protect from light, heat, and moisture.
- Shipping Information: Transport according to local regulations. Ensure containers are secure and upright during transit to prevent leaks.
Transport Information
- UN Number: Not classified as hazardous for transport
- Hazard Class: Not classified
- Packing Group: Not classified
- Proper Shipping Name: Not classified
Specifications
- Purity: Typically >98%
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- 2-Bromophenol: Used in similar applications for organic synthesis and pharmaceutical intermediates.
- Phenol: A basic building block in organic chemistry, used in the production of resins, plastics, and pharmaceuticals.
- 4-Bromoaniline: Another brominated compound used in the synthesis of dyes, pharmaceuticals, and agrochemicals.
- Brominated Compounds: Various compounds used in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals.
By understanding the chemical properties, applications, and safety measures of 4-bromophenol, researchers and industry professionals can effectively utilize this versatile compound in various scientific and industrial processes while ensuring safety and regulatory compliance.