4-Bromoaniline

Introduction

4-Bromoaniline is a highly significant aromatic amine featuring a bromine atom attached to the benzene ring. Due to its unique structure and reactivity, it plays a crucial role in various industrial applications, particularly in synthesising pharmaceuticals, dyes, and agrochemicals. This blog will explore its properties, applications, safety considerations, and market availability.

Chemical Description

IUPAC Name: 4-Bromoaniline
Synonyms: p-Bromoaniline, p-Bromoaminobenzene, 1-Bromo-4-aminobenzene
CAS Number: 106-40-1
Molecular Formula: C6H6BrN
Molecular Weight: 172.02 g/mol
Appearance: White to off-white crystalline solid

Physical and Chemical Properties

4-Bromoaniline is typically found in solid form and has the following physicochemical characteristics:

Melting Point: 66-68°C (150.8-154.4°F)
Boiling Point: 243°C (469.4°F)
Density: 1.6 g/cm³
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform

These properties make 4-bromoaniline a versatile compound in numerous chemical reactions.

Industrial Applications

4-Bromoaniline is a valuable intermediate in various chemical synthesis processes. Some of its major applications include:

1. Pharmaceuticals

4-Bromoaniline is extensively used as an intermediate in synthesising numerous pharmaceutical compounds. Its brominated structure provides a reactive site for modifications that lead to the production of drugs treating different medical conditions.

2. Dyes and Pigments

This compound plays a key role in the dye industry by serving as a precursor in producing vibrant and stable dyes. These dyes are widely used in textiles, inks, and coatings.

3. Agrochemicals

The agrochemical industry relies on 4-bromoaniline to synthesise pesticides and herbicides. Its molecular structure allows the development of potent formulations that enhance crop protection.

Market Availability and Pricing

4-Bromoaniline is available in various packaging sizes, catering to research and industrial-scale applications. Pricing varies based on factors such as:

Quantity required
Purity level
Supplier and geographic location

For specific pricing details and bulk order inquiries, contacting suppliers directly or visiting their online stores is best.

Safety and Toxicology

Due to its toxic nature, handling 4-bromoaniline requires caution. Below are some safety considerations:

Hazard Statements (GHS Classification)

H302: Harmful if swallowed
H312: Harmful in contact with skin
H332: Harmful if inhaled
H315: Causes skin irritation
H319: Causes severe eye irritation

Precautionary Measures

P280: Wear protective gloves, clothing, and eye protection
P302+P352: In case of skin contact, wash thoroughly with soap and water
P305+P351+P338: If it gets into the eyes, rinse cautiously with water for several minutes and remove contact lenses if possible
P301+P330+P331: If swallowed, rinse the mouth but do not induce vomiting

Storage and Transport

To ensure safety and stability, proper storage conditions must be maintained:

Store in a cool, dry, and well-ventilated area
Keep the container tightly closed and away from incompatible substances
Follow hazardous material regulations when shipping

Transport Information

UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (4-Bromoaniline)
Hazard Class: 6.1
Packing Group: III

Product Specifications

4-Bromoaniline is typically supplied with the following specifications:

Purity: ≥ 98%
Impurities: ≤ 2%
Appearance: White to off-white crystalline solid
Melting Point Range: 66-68°C
Boiling Point: 243°C
Solubility: Slightly soluble in water, soluble in organic solvents

Conclusion

4-Bromoaniline is an essential chemical intermediate with widespread industrial applications, especially in pharmaceuticals, dyes, and agrochemicals. Its distinct properties and reactivity make it indispensable in chemical synthesis. However, strict handling and safety measures should always be followed. due to toxicity. Whether for research or large-scale industrial use, this compound remains critical in various scientific advancements. The continued demand for 4-Bromoaniline highlights its significance in the global chemical industry, ensuring ongoing research and development in new applications and improved safety measures.