Overview
4-Bromophenol is an aromatic organic compound used extensively in chemical syntheses and various industrial applications. Known for its bromine-substituted phenol structure, this compound is a valuable intermediate in producing pharmaceuticals, agrochemicals, and fine chemicals. This post provides a detailed overview of 4-bromophenol, including its chemical properties, applications, and safety measures.
Description
4-Bromophenol is a white to off-white crystalline solid with a characteristic phenolic odour. It features a bromine atom substituted at the para position of the phenol ring, making it highly reactive and helpful in various organic synthesis reactions.
Product Information
- IUPAC Name: 4-Bromophenol
- Common Name: p-Bromophenol
- CAS Number: 106-41-2
- Molecular Formula: C₆H₅BrO
- Molecular Weight: 173.01 g/mol
- Chemical Structure:
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Applications
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Organic Synthesis
- 4-Bromophenol is widely used as an intermediate in organic synthesis. It prepares various brominated compounds essential in developing pharmaceuticals and fine chemicals.
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Pharmaceuticals
- This compound is a building block in synthesizing intermediates and active pharmaceutical ingredients (APIs).
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Agrochemicals
- Used in the synthesis of agrochemicals, including insecticides, herbicides, and fungicides, contributing to improved agricultural productivity.
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Dyes and Pigments
- Employed in producing dyes and pigments, providing colour and stability to various products.
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Chemical Research
- Utilized initialized and industrial research to study reaction mechanisms, develop new synthetic methodologies, and produce novel brominated compounds.
Physicochemical Information
- Molecular Formula: C₆H₅BrO
- Molecular Weight: 173.01 g/mol
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Safety Information According to GHS
- Hazard Statements:
- H315: Causes skin irritation
- H319: Causes ssevereeye irritation
- H335: May cause respiratory irritation
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Precautionary Statements:
- P261: Avoid breathing dust/fume/gas/mist/vavapourspray.
- P280: Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352: IF ON SKIN: Wash with plenty of soap and water.
- P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. If contact lenses are present and easy to remove, continue rinsing.
- P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
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Safety Information
- Hazards: 4-Bromophenol can irritate the skin, eyes, and respiratory system. Handle with care to avoid exposure.
- Protective Measures: Use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. Work with 4-bromophenol should be conducted in a well-ventilated area, preferably in a fume hood.
- Storage: Store in tightly sealed containers, away from light, heat, and incompatible substances.
Storage and Shipping Information
- Storage Conditions: Store in tightly sealed containers in a cool, dry place. Protect from light, heat, and moisture.
- Shipping Information: Transport according to local regulations. Ensure containers are secure and upright during transit to prevent leaks.
Transport Information
- UN Number: Not classified as hazardous for transport
- Hazard Class: Not classified
- Packing Group: Not classified
- Proper Shipping Name: Not classified
Specifications
- Purity: Typically >98%
- Appearance: White to off-white crystalline solid
- Melting Point: 63-66°C
- Boiling Point: 236-238°C
- 2-Bromophenol: Used in similar applications for organic synthesis and pharmaceutical intermediates.
- Phenol: A fundamental building block in organic chemistry, used in producing resins, plastics, and pharmaceuticals.
- 4-Bromoaniline: Another brominated compound used to synthesize synthesizemaceuticals and agrochemicals.
- Brominated Compounds: Various compounds are used in synthesizinsynthesizingicals, agrochemicals, and fine chemicals.
By understanding the chemical properties, applications, and safety measures of 4-bromophenol, researchers and industry professionals can effectively utilize these compounds in various scientific and industrial processes while ensuring safety and regulatory compliance.