Overview
Triethylsilane, commonly abbreviated as TES, is an organosilicon compound extensively utilized in organic synthesis and industrial applications. TES is pivotal in various chemical processes because it is known for its versatility as a reducing agent. This post delves into its chemical properties, applications, and safety measures, providing an extensive guide for researchers and industry professionals.
Description
Triethylsilane is a colorless liquid with a mild odor, notable for its stability and reactivity. It features a silicon atom bonded to three ethyl groups, contributing to its unique properties. This organosilicon compound is frequently used in reducing organic compounds and as a protective agent in peptide synthesis.
Product Information
- IUPAC Name: Triethylsilane
- Common Name: TES
- CAS Number: 617-86-7
- Molecular Formula: C₆H₁₆Si
- Molecular Weight: 116.28 g/mol
- Appearance: Colorless liquid
- Boiling Point: Approximately 107-109°C
- Density: 0.726 g/cm³
- Solubility: Soluble in organic solvents like hexane, toluene, and ether; insoluble in water
Applications
- Organic Synthesis: Widely utilized as a hydride donor in reductions.
- Peptide Synthesis: Scavenges reactive species and stabilizes intermediates, ensuring high-purity peptide production.
- Drug Development: Used in synthesizing various drug compounds, particularly those requiring mild reducing conditions.
- Catalysis: Enhances reaction rates and selectivities, especially in asymmetric synthesis and fine chemical processes.
Physicochemical Information
- Molecular Formula: C₆H₁₆Si
- Molecular Weight: 116.28 g/mol
- Boiling Point: 107-109°C
- Density: 0.726 g/cm³
- Solubility: Soluble in organic solvents; insoluble in water
Safety Information According to GHS
- Hazard Statements:
- H225: Highly flammable liquid and vapor
- H315: Causes skin irritation
- H319: Causes serious eye irritation
- H335: May cause respiratory irritation
- Precautionary Statements:
- P210: Keep away from heat, hot surfaces, sparks, open flames, and other ignition sources. No smoking.
- P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
- P280: Wear protective gloves/protective clothing/eye protection/face protection.
Safety Information
- Hazards: Flammable and irritant to skin, eyes, and respiratory system. Inhalation of vapors may cause dizziness and headaches.
- Protective Measures: Use appropriate PPE such as gloves, safety goggles, and lab coats. Conduct work in a well-ventilated area, preferably in a fume hood.
- Storage: Store in tightly sealed containers made of compatible materials, away from ignition sources and strong oxidizing agents.
Storage and Shipping Information
- Storage Conditions: Store in a cool, dry place in tightly sealed containers. Keep away from sources of ignition and incompatible substances.
- Shipping Information: Transport according to local regulations. Ensure containers are secure and upright during transit to prevent leaks
Transport Information
- UN Number: 1993
- Hazard Class: 3 (Flammable liquids)
- Packing Group: II
- Proper Shipping Name: Flammable liquid, n.o.s. (contains Triethylsilane)
Specifications
- Purity: Typically >98%
- Appearance: Clear, colorless liquid
- Boiling Point: 107-109°C
- Density: 0.726 g/cm³
Related Products & Applications
- Triisopropylsilane (TIPS): Used similarly to TES in reductions and peptide synthesis.
- Diethylsilane: Another silane used in organic synthesis and as a reducing agent.
- Tetramethyldisiloxane: Utilized in hydrosilylation and as a protecting group in organic synthesis.
- Silicon-based Catalysts: Employed in various catalytic processes, enhancing reaction efficiency and selectivity.
By understanding the chemical properties, applications, and safety measures of triethylsilane, researchers and industry professionals can effectively utilize this versatile reagent in various scientific and industrial processes while ensuring safety and regulatory compliance.