Chemical Name: 4-Bromo Phenol
Molecular Formula: C6H5BrO
CAS Number: 106-41-2
Molecular Weight: 173.01 g/mol
Appearance: White to off-white crystalline solid
Melting Point: 63-67°C
Boiling Point: 236-238°C
Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
Table of Contents
| Section | Details |
|---|---|
| 1. Introduction | Overview of 4-Bromo Phenol, including its significance in organic synthesis |
| 2. Chemical Properties | Detailed description of the key chemical and physical properties of 4-Bromo Phenol |
| 3. Synthesis and Production | Methods used in the synthesis and industrial production of 4-Bromo Phenol |
| 4. Applications | Overview of the primary applications of 4-Bromo Phenol in various industries |
| 5. Safety and Handling | Guidelines for the safe handling, storage, and disposal of 4-Bromo Phenol |
| 6. Environmental Impact | Discussion of the environmental impact and regulatory considerations of 4-Bromo Phenol |
| 7. Comparison with Related Compounds | Analysis of how 4-Bromo Phenol compares to other halogenated phenols |
| 8. Research and Studies | Summary of recent research on the use of 4-Bromo Phenol in chemical processes |
| 9. Market and Supply Chain | Overview of the market demand, suppliers, and global trade of 4-Bromo Phenol |
| 10. Conclusion | Final thoughts on the importance and future prospects of 4-Bromo Phenol |
1. Introduction
4-Bromo Phenol, also known as p-Bromophenol, is a halogenated phenol that is widely used in organic synthesis. The compound features a bromine atom attached to the para position of the phenol ring, giving it distinct reactivity compared to other phenol derivatives. This reactivity makes 4-Bromo Phenol a valuable intermediate in the production of pharmaceuticals, agrochemicals, and dyes.
2. Chemical Properties
4-Bromo Phenol is characterized by the following key properties:
- Molecular Formula: C6H5BrO
- Molecular Weight: 173.01 g/mol
- Appearance: White to off-white crystalline solid
- Melting Point: 63-67°C
- Boiling Point: 236-238°C
- Solubility: Slightly soluble in water; soluble in organic solvents such as ethanol, ether, and chloroform
The presence of the bromine atom enhances the reactivity of the phenol ring, making 4-Bromo Phenol a useful reagent in electrophilic substitution reactions. The compound’s moderate solubility in water and good solubility in organic solvents allow for versatility in various chemical processes.
3. Synthesis and Production
4-Bromo Phenol is typically synthesized through the bromination of phenol using bromine or a brominating agent such as N-bromosuccinimide (NBS). The reaction is usually carried out under controlled conditions to ensure selective substitution at the para position. The crude product is then purified through recrystallization or distillation to achieve high purity.
The simplicity and efficiency of this synthetic route make 4-Bromo Phenol accessible for both small-scale laboratory use and large-scale industrial production.
4. Applications
4-Bromo Phenol has a wide range of applications across various industries:
- Pharmaceuticals: It serves as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those involving aromatic substitution reactions.
- Agrochemicals: The compound is used in the production of herbicides, fungicides, and other agrochemical products.
- Dye Synthesis: 4-Bromo Phenol is a precursor in the manufacture of dyes and pigments, where its halogenated structure contributes to colorfastness and stability.
- Research: In academic and industrial research, 4-Bromo Phenol is used to study halogenated phenols and their reactivity in various chemical reactions.
5. Safety and Handling
4-Bromo Phenol should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system. Safety guidelines include:
- Personal Protective Equipment (PPE): Wear gloves, safety goggles, and a lab coat when handling 4-Bromo Phenol.
- Storage: Store in a cool, dry place, away from heat and direct sunlight. Ensure the container is tightly closed when not in use.
- Disposal: Dispose of 4-Bromo Phenol in accordance with local environmental regulations, typically as hazardous chemical waste.
In case of accidental exposure, immediately rinse the affected area with plenty of water and seek medical attention if necessary.
6. Environmental Impact
While 4-Bromo Phenol is not highly toxic, care should be taken to prevent its release into the environment. The compound can be harmful to aquatic life, so proper disposal methods are essential to minimize environmental impact. Regulatory guidelines should be followed to ensure compliance with environmental protection standards.
7. Comparison with Related Compounds
4-Bromo Phenol is often compared with other brominated phenols, such as 2-Bromo Phenol and 3-Bromo Phenol. The position of the bromine atom on the phenol ring significantly influences the compound’s reactivity and applications. For example, 4-Bromo Phenol is more commonly used in para-selective substitution reactions, whereas 2-Bromo Phenol and 3-Bromo Phenol may be preferred for ortho- or meta-selective reactions, respectively.
8. Research and Studies
Recent research on 4-Bromo Phenol has focused on its role in the synthesis of new organic compounds, particularly those with potential pharmaceutical applications. Studies have explored the compound’s reactivity in various substitution reactions, as well as its use as a starting material for more complex molecules.
9. Market and Supply Chain
4-Bromo Phenol is readily available from chemical suppliers worldwide. Its demand is primarily driven by the pharmaceutical and agrochemical industries, with additional interest from dye manufacturers and research institutions. The compound is typically sold in bulk quantities, with pricing influenced by purity, quantity, and regional demand.
10. Conclusion
4-Bromo Phenol is a versatile and widely used compound in organic synthesis. Its unique chemical properties, combined with its broad range of applications, make it an essential reagent in various industries. Understanding its properties, safe handling practices, and environmental impact is crucial for professionals working with this compound. As research continues to expand its potential uses, 4-Bromo Phenol is expected to remain a valuable asset in modern chemistry.
FAQ
It serves as a fundamental building component in the synthesis of many different chemical molecules.
Answer: You have to brominate Phenol in carbon disulfide to obtain 4-Bromophenol. At -30° C, 4-bromophenol is yielded by 97% and at +30° C, the yield is 82%. …
The 4-Bromo-2-chlorophenols of formula I are valuable intermediates for producing insecticidal and acaricidal active substances.
Bromophenol is also used as a colour marker to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis.
