Introduction to Triisopropylsilane
Triisopropylsilane, commonly called TIPS, is an organosilicon compound widely used in organic chemistry and the pharmaceutical industry. Known for its stability and versatility, TIPS is a crucial reagent in various chemical processes. This blog post delves into the chemical properties, applications, and safety measures associated with triisopropylsilane, providing a comprehensive overview for researchers and industry professionals.
Chemical Information
- IUPAC Name: Triisopropylsilane
- Common Name: TIPS
- CAS Number: 6485-79-6
- Molecular Formula: C₉H₂₂Si
- Molecular Weight: 158.36 g/mol
Structure and Properties
Triisopropylsilane features a silicon atom bond to three isopropyl groups, which gives it a unique structure and contributes to its chemical properties.
- Appearance: Colorless liquid with a mild odor
- Boiling Point: Approximately 181-183°C
- Density: 0.764 g/cm³
- Solubility: Soluble in organic solvents like hexane, toluene, and ether; insoluble in water
Chemical Behavior
Triisopropylsilane is known for its stability under normal conditions. It is frequently used as a reducing agent in organic synthesis, particularly for deprotection reactions.
- Reactivity: Stable compound that reacts with strong oxidizing agents
- Stability: Maintains stability under normal conditions but requires careful handling
Applications of Triisopropylsilane
The versatility of triisopropylsilane makes it a valuable reagent in several industrial and scientific applications.
- Organic Synthesis
- TIPS is widely utilized as a hydride donor in reductions and the deprotection of silyl ethers, making it an essential reagent in organic synthesis.
- Peptide Synthesis
- In peptide synthesis, TIPS helps scavenge reactive species and stabilize intermediates, ensuring the production of high-purity and high-yield peptides.
- Drug Development
- The pharmaceutical industry employs TIPS to synthesize various drug compounds, especially those involving sensitive intermediates requiring mild reducing conditions.
- Catalysis
- TIPS enhances reaction rates and selectivities in catalytic systems, particularly in asymmetric synthesis and other fine chemical processes.
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- Safety and Handling
Given its chemical properties, triisopropylsilane must be handl carefully to ensure safety.
- Hazards: TIPS is flammable and can cause skin, eye, and respiratory irritation. Inhalation of vapors may result in dizziness and headaches.
- Protective Measures: Always use appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. Work with TIPS in a well-ventilat area, preferably in a fume hood.
- Storage: Store TIPS in tightly seal containers made of compatible materials, away from ignition sources and strong oxidizing agents.
Environmental Impact
While triisopropylsilane is relatively stable in the environment, if not manag correctly, it can contribute to air and water pollution.
- Degradation: TIPS is stable but can have environmental impacts if releas in significant quantities.
- Disposal: Dispose of TIPS according to local regulations, typically requiring containment and disposal as hazardous waste.
Regulatory Information
Triisopropylsilane is regulat due to its flammability and potential health hazards.
- Regulatory Status: Subject to various national and international guidelines regarding its handling, storage, and disposal.
Conclusion
Understanding the chemical properties, applications, and safety measures of triisopropylsilane allows researchers and industry professionals to utilize this versatile reagent effectively. By adhering to proper handling and regulatory guidelines, the benefits of TIPS can be maximiz while ensuring safety and environmental protection.